Prof. Tatsuhiko Kodama

Professor, Department for Systems Biology and Medicine
Director, Laboratory for Systems Biology and Medicine
Research Center for Advanced Science and Technology, The University of Tokyo

University of Tokyo, Tokyo, Japan, M.D. 1977         Medicine
University of Tokyo, Tokyo, Japan, Ph.D. 1984         Medicine

Major research interest

Osteoprotection by semaphorin 3A.
Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H. Nature. 2012 May 3;485(7396):69-74.

Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis.
Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, Shibuya M.
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20725-

Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T.
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Nature. 2007 Jul 26;448(7152):501-5.

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.
Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani L, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T.
Nature. 2009 Nov 5;462(7269):99-103.

Wada Y, Ohta Y, Xu M, Tsutsumi S, Minami T, Inoue K, Komura D, Kitakami J, Oshida N, Papantonis A, Izumi A, Kobayashi M, Meguro H, Kanki Y, Mimura I, Yamamoto K, Mataki C, Hamakubo T, Shirahige K, Aburatani H, Kimura H, Kodama T, Cook PR, Ihara S.
A wave of nascent transcription on activated human genes.
Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18357-61

Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T,  Kodama T.
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.  Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17278-83.

Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J.
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
Nature. 2006 Jan 26;439(7075):484-9.

Koga T, Inui M, Inoue K, Kin S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Tniguchi T, Takayanagi H, Takai T.
ITAM-mediated costimulatory signals cooperate with RANKL for bone homeostasis.
Nature 2004 428(6984):758-63.

Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K,Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J.
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.
Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26): 15924-9.

Cynshi O, Kawabe Y, Suzuki T, Takashima Y, Kaise H, Nakamura M, Ohba Y, Kato Y, Tamura K, Hayasaka A, Higashida A, Sakaguchi H, Takeya M, Takahashi K, Inoue K, Noguchi N, Niki E and Kodama T.
Antiatherogenic effects of the antioxidant BO-653 in three different animal model
Proc. Natl. Acad. Sci USA  1998, 95, 10123-10128

Suzuki H, Kurihara Y, Takeya M, Kamada N, Kataoka M, Jishage K, Ueda O, Sakaguchi H, Higashi T, Suzuki T, Takashima Y, Kawabe Y, Cynshi O, Wada Y, Honda M, Kurihara H, Aburatani H, Doi T, Matsumoto A, Azuma S, Noda T, Toyoda Y, Itakura H, Yazaki Y, Horiuchi S, Takahashi K, Kruijt J-K, van Berkel T-J-C, Steinbrecher U-P, Ishibashi S, maeda N, Gordon S & Kodama T.  Resistance to atherosclerosis and susceptibility to infection in scavenger receptor knockout mice
Nature, 1997, 386, 292-6

Mato M, Ookawara S, Sakamoto A, Aikawa E, Ogawa T, Mitsuhashi U, Masuzawa T, Suzuki H, Honda M, Yazaki Y, Watanabe E, Luoma J, Yla-Herttuala S, Fraser I, Gordon S. Kodama, T.
Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex.
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3269-74.

Kurihara, Y., Kurihara, H., Suzuki, H.,  Kodama, T.,  Maemura, K., Nagai, R., Oda, H., Kuwaki, T., Cao, W-H., Kamata, N., Jishage, K., Ouchi, Y., Azuma, S., Toyoda, Y., Ishikawa, T., Kumada, M.,& Yazaki, Y. (1994). Disruption of mouse endothelin-1 gene results in lethality and craniofacial anomaly in homozygotes and elevated blood pressure in heterozygotes.  Nature, 368, 703-710

Matsumoto, A., Naito, M., Itakura, H., Ikemoto, S., Asaoka, H., Hayakawa, I., Kanamori, H.,  Aburatani, H., Takaku, F., Suzuki, H. Kobari, Y., Miyai, T., Takahashi, K., Cohen, E.H., Wydro, R., Housman, D.E., & Kodama, T.(1990).
Human macrophage scavenger receptors:  Primary structure, expression, and localization in atherosclerotic lesions. 
Proc Natl Acad Sci U S A, 87(23), 9133-9137.

Kodama, T., Freeman, M., Rohrer, L., Zabrecky, J., Matsudaira, P., & Krieger, M. (1990).
Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils. 
Nature, 343(6258), 531-535.

Rohrer, L., Freeman, M., Kodama, T., Penman, M., & Krieger, M. (1990).
Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II.
Nature, 343(6258), 570-572.

Kodama, T., Reddy, P., Kishimoto, C., & Krieger, M. (1988).
Purification and characterization of a bovine acetyl low density lipoprotein receptor. 
Proc Natl Acad Sci U S A, 85(23), 9238-9242.