Diet, remnant cholesterol and Non-Alcoholic Fatty Liver Disease (NAFLD)
This analysis of the MEDIDIET study investigated the effect of different diets on remnant cholesterol levels in patients with metabolic syndrome, as well as the association between NAFLD and remnant cholesterol. In total, 237 individuals were randomly assigned to the Mediterranean diet (MD), Low Glycaemic Index diet (LGID), or Low Glycaemic Index Mediterranean diet (LGIMD). Remnant cholesterol was calculated as [total cholesterol-low density lipoprotein cholesterol (LDL-C)-high density lipoprotein cholesterol (HDL-C)]. Liver ultrasound was performed at baseline, 3 and 6 months to assess the NAFLD score. All three dietary interventions reduced levels of remnant cholesterol at 3 and 6 months; the effect was stronger among the group assigned to the LGIMD. Remnant cholesterol was independently associated with the severity of NAFLD. In conclusion, the Mediterranean dietary pattern may be a useful strategy for reducing remnant cholesterol and the severity of NAFLD in patients with metabolic syndrome.
The effect of three Mediterranean diets on remnant cholesterol and Non-Alcoholic Fatty Liver Disease: a secondary analysis.
Campanella A, Iacovazzi PA, Misciagna G, et al.