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Residual cardiovascular risk: an evolving concept

Despite best evidence-based management including well-controlled low-density lipoprotein cholesterol levels (LDL-C), high-risk patients continue to be at risk of cardiovascular events. This implies that there are other drivers of residual risk, which are often unrecognized and therefore not addressed in clinical practice. This review discusses the contribution of inflammatory, pro-thrombotic, and metabolic pathways to residual cardiovascular risk. Among the potential contributors to residual metabolic risk, the focus is on triglyceride-rich lipoproteins and their remnants, lipoprotein(a) and diabetes. The authors underline the need for a personalized approach to risk prediction and subsequent treatment of high-risk patients in routine practice.
The evolving understanding and approach to residual cardiovascular risk management.

Dhindsa DS, Sandesara PB, Shapiro MD, Wong ND.