Inflammatory residual risk in diabetes: how prevalent?
Beyond lipids, inflammation may be an important contributor to residual cardiovascular risk in type 2 diabetes patients, according to this analysis. The study evaluated data from 511 type 2 diabetes patients, stratified for statin use, attainment of low-density lipoprotein cholesterol (LDL-C) goal and the presence of diabetes complications. Residual inflammatory risk was defined as persistent circulating levels of high sensitivity C-reactive protein (hs-CRP) >2 mg/L despite well controlled LDL-C levels (<70 mg/dL or <1.8 mmol/L). In this group, 39.2% of type 2 diabetes patients had residual inflammatory risk, and prevalence was even higher among patients with diabetic nephropathy. Glucose-associated variables were strongly associated with residual inflammatory risk in patients at LDL-C goal. Overall, the findings suggest that glycaemic control, insulin resistance, non-LDL-C lipid variables and central obesity are implicated in residual inflammatory risk in type 2 diabetes patients with well controlled LDL-C levels.
Prevalence of residual inflammatory risk and associated clinical variables in patients with type 2 diabetes.
Prattichizzo F, Giuliani A, Sabbatinelli J, et al.