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Understanding remnants and their role in cardiovascular disease in diabetes

This timely review discusses the evidence for remnant lipoprotein particles as a contributor to residual cardiovascular risk. Remnant lipoproteins are derived from the lipolysis of very low-density lipoproteins (VLDL, containing apolipoprotein B100) and chylomicrons (containing apolipoprotein B48). These lipoprotein particles vary in size and composition, and are enriched in cholesteryl esters and apolipoprotein E. The authors highlight the need for a generally accepted definition of remnant lipoproteins, as well as standardisation in their measurement. Both are essential to understanding the role of remnant lipoproteins in promoting atherosclerotic cardiovascular disease.
Remnants of the triglyceride-rich lipoproteins, diabetes, and cardiovascular disease.

Chait A, Ginsberg HN, Vaisar T et al.