Triglyceride: high-density lipoprotein cholesterol ratio and risk of type 2 diabetes
Data from the Beijing Longitudinal Study of Aging indicate that the ratio of triglycerides to high-density lipoprotein cholesterol (TG:HDL-C) is associated with future risk of type 2 diabetes mellitus in the Chinese population. This analysis included data from 1,460 subjects (733 men and 727 women, mean age at baseline 68.8 years) followed for up to 25 years. Overall, the cumulative incidence of new-onset type 2 diabetes mellitus was 8.42 per 1000 person-years. Individuals with a time-dependent TG/HDL-C ratio of 1.31–1.74 and ≥1.75 had a 2.75- and 2.84-fold higher risk of developing type 2 diabetes mellitus, respectively, compared with those with a ratio <0.87. These findings indicate that the TG/HDL-C ratio is an independent risk factor for developing type 2 diabetes mellitus. The authors concluded that lowering the TG/HDL-C ratio may be a preventive measure against the development of type 2 diabetes mellitus in the general population, re-emphasizing the importance of monitoring the lipid profile in clinical practice.
Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of type 2 diabetes mellitus among Chinese elderly: the Beijing Longitudinal Study of Aging.
Zheng D, Li H, Ai F et al