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Metabolic syndrome recovery reduces risk for cardiovascular events

Recovery from the metabolic syndrome resulted in a corresponding decreased risk for major adverse cardiovascular events (MACE), according to a recent report. This study included 9,553,042 patients (aged ≥20 years) sampled from the National Health Insurance Database of Korea, who were screened from 2009 to 2014. None had a pre-existing history of cardiovascular disease. Metabolic syndrome was defined as the presence of three or more of the following components: elevated triglyceride level or use of a relevant drug, increased waist circumference, elevated blood pressure or use of an antihypertensive medication, reduced high-density lipoprotein cholesterol or use of a relevant drug, and elevated fasting glucose level or the use of an antidiabetic drug. Individuals were categorized based on metabolic syndrome status at three follow-up visits. MACE was defined as revascularization, acute myocardial infarction and/or acute ischaemic stroke. During follow-up, individuals who had the metabolic syndrome at the first visit but not at the second and third visits had a lower risk for MACE (incidence rate, 4.55 per 1,000 person-years) compared with those with the metabolic syndrome at all three visits (incidence rate, 8.52 per 1,000 person-years). In addition, individuals who developed the metabolic syndrome during the study had about a three-fold higher risk for MACE than those who did not (incidence rates, 6.05 per 1,000 person-years vs1.92 per 1,000 person-years; adjusted incidence rate ratio = 1.36; 95% CI, 1.33-1.39). According to the researchers, the results of the study make the case for renewed efforts directed at prevention and recovery from the metabolic syndrome to reduce the socioeconomic burden of cardiovascular disease.
Altered risk for cardiovascular events with changes in the metabolic syndrome status: a nationwide population-based study of approximately 10 million persons.

Park S, Lee S, Kim Y et al.