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In this new analysis, investigators evaluated the relationship between niacin treatment, lipoproteins and their subfractions, and cardiovascular outcomes in 2457 patients in the AIM-study at baseline and after 1 year of treatment. Overall, they showed that apoliprotein(apo) B-containing lipoproteins and their subfractions decreased and HDL-C and its subfractions increased more in patients treated with niacin than placebo. Among the subgroup with atherogenic dyslipidaemia (elevated triglycerides and low HDLC) treated with niacin, the data suggested that a reduction in levels of remnant lipoprotein cholesterol (very low-density lipoprotein cholesterol and its subfractions and total remnant lipoproteins) at 1 year, and an increase of HDL subclass HDL2-C were associated with reduced cardiovascular risk. The AIM-HIGH investigators make the case, however, that this post hoc analysis is solely hypothesis-generating and requires further evaluation.