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Serum C-peptide: a contributor to lipid-related residual risk in the elderly?

Serum levels of C-peptide, an important risk factor for cardiovascular disease, are known to increase with age. This population-based cross-sectional study showed a strong association between serum C-peptide and elevated triglycerides and low plasma concentration high-density lipoprotein cholesterol (HDL-C) suggesting that C-peptide may be implicated in the residual cardiovascular risk associated with atherogenic dyslipidaemia in the elderly.
The study included 3,091 elderly subjects aged ?65 years. Serum triglycerides and HDL-C levels were significantly associated with changes in serum C-peptide levels, independent of insulin levels. Additionally, there was evidence of a significant dose-response association in both men and women.
Serum C-peptide as a key contributor to lipid-related residual cardiovascular risk in the elderly.

Li Y, Zhao D, Li Y et al.