Recent publications on Residual Risk

This timely perspective highlights the unmet clinical need due to non-low-density lipoprotein abnormalities that contribute to residual cardiovascular risk in high risk patients. In particular, the report highlights the marked increase in the prevalence of atherogenic dyslipidaemia, characterised by hypertriglyceridaemia, low plasma concentration of high-density lipoprotein (HDL) cholesterol, and qualitative changes in LDL particles. The increase in the prevalence of this dyslipidaemic profile has been especially notable in Latin and South America and South East Asia, in line with adoption of a sedentary lifestyle and Westernised diet on top of high habitual carbohydrates intake. This review discusses the underlying pathophysiology contributing to the development of this dyslipidaemia, current therapeutic options, as well as novel therapeutic strategies that target elevated triglyceride-rich lipoprotein particles which may offer promise in reducing the high residual cardiovascular risk.