Recent publications on Residual Risk

In this experimental study in rabbits, the HDL mimetic CER-522 improved left ventricular diastolic dysfunction as well as decreasing macrophage accumulation, cardiomyocyte apoptosis, coronary atherosclerosis and remodeling. Experimental left ventricular dysfunction was induced in rabbits fed a cholesterol- and vitamin D2-enriched diet. Subsequently, the rabbits were treated with 10 mg/kg or 30 mg/kg CER-522 infusions 6 times over 2 weeks, or saline infusions (control). Serial echocardiograms and left ventricular histology showed that CER-522 reduced a number of variables indicative of left ventricular diastolic dysfunction, including early filling mitral deceleration time, deceleration rate, and the left ventricular diastolic dysfunction score. Furthermore, CER-522 infusion also reduced macrophage accumulation in the left ventricle, levels of apoptotic cardiomyocytes, as well as atheromatous plaques in the coronary arteries. The results of this study merit further study of CER-522.