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The current study compared the effect of pemafibrate (0.0005%) or fenofibrate (0.05%), in a mouse model of diet-induced hypertriglyceridaemia. Treatment with pemafibrate was shown to decrease postprandial levels of triglycerides and apolipoprotein B-48, as well as reduce the postprandial accumulation of triglyceride-rich lipoproteins and chylomicron remnants. These findings suggest that pemafibrate may have potential benefit in attenuation of postprandial hypertriglyceridaemia, a risk factor for cardiovascular disease.