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Alzheimer’s dementia linked with metabolic syndrome

This review highlights accumulating evidence which suggests a link between dysfunctional insulin signalling and glucose metabolism in the brain and subsequent development of Alzheimer’s dementia. Indeed, recent studies have suggested the importance of controlling blood glucose levels, regardless of a diagnosis of diabetes mellitus, as early as midlife for prevention of late-life dementia. The authors draw attention to therapeutic efforts targeting oxidative stress which could have potential in reducing amyloid Beta-induced neurotoxicity and improving neurological outcome in patients with Alzheimer’s dementia.
Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration.

Rojas-Gutierrez E, Muñoz-Arenas G, Treviño S et al.